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Non-Replicative Virus Particles for Safe Neutralization Assays
Integral Molecular® Reporter Virus Particles (RVPs) are for scientists working to develop vaccines, antibodies, and other countermeasures against the world’s deadliest and most challenging viruses.
RVPs are non-replicative virus-like particles with surface proteins from a diverse range of viruses. They are a safe, ready-to-use substitute for live virus, ideal for infectivity and neutralization assays.
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“There are some hurdles to running live virus neutralization assays. RVPs made it easy to triage leads across many viral variants. The luciferase RVP assay was very easy to run, and it helped us identify mAbs with neutralizing activity against all the variants we tried.”
-CHUN-NAN CHEN, PHD, CEO & CSO, SINGLE CELL TECHNOLOGY
Case Studies: See how our customers have used RVPs
To see more case studies, plus publications and webinars, visit the Resources page
Reporter Virus Particles are available directly through our website or through our partner distributors.
Featured White Paper: Using Pseudoviruses in Neutralization Assays
Learn why virologists are increasingly turning to pseudoviruses as an alternative to live virus.
Download the white paper
What viral cores do you use in RVPs?
- Most of our catalog products, including SARS-CoV-2 RVPs and Influenza RVPs, are pseudoviruses built on a lentivirus core derived from HIV. This established and versatile platform allows us to quickly optimize and produce RVPs for many new viruses and variants.
- Flavivirus RVPs use own-virus proteins for the most authentic representation of virus behavior while still being non-replicating. To learn more about this pseudoinfective virus-like particle system, visit the Takeda case study.
- HIV and Rabies RVPs are pseudoviruses built on a distinctly bullet-shaped VSV core (from vesicular stomatitis virus). For certain viral surface proteins, the VSV system can yield a higher concentration than can be achieved with the lentivirus core system.
Are RVPs the same as live virus?
How are RVPs used?
What is the RVP readout?
What vaccine development services do you offer?
What options do you offer for custom RVP projects?
Do you offer large lots or volumes of RVPs?
What’s the difference between RVPs and influenza TiterSafe particles?
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